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CuCl 2 and Cu(OAc) 2 were significantly more cytotoxic ( p 0.05

doi:10.1146/annurev.nutr.20.1.457 ^ Witard O.C., Hearris M., Morgan P.T

Moreover, there were no significant distinctions observed between the CUR@DssD-Hb NPs and CUR/miR155@DssD-Hb NPs groups regarding CRT externalization and the release of HMGB1 and ATP in both B16F10 and 4T1 cells

Saari (98) demonstrated that dietary copper deficiency resulted in various cardiovascular defects with systemic effects including hypertension, increased inflammation, anaemia decreased blood clotting and possibly atherosclerosis, which also has effects on specific organs or tissues such as diminished structural integrity of the heart and blood vessels, impaired energy use by the heart, decreased contractility of the heart, altered ability for blood vessels to control their diameter growth and structural-functional changes in circulating blood cells